Site Specific Discrete PEGylation of124I-Labeled mCC49 Fab′ Fragments Improves Tumor MicroPET/CT Imaging in Mice
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چکیده
منابع مشابه
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and Ser, provides a convenient way to expand protein size and, consequently, retard renal filtration...
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The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant problems still remain with their use. Among these problems are rapid degradation and excretion from patients, thus requiring frequent dosing, which in turn increases the chances for an immunological response as wel...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2013
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc400375f